NCDC On High Alert After Confirmation Of Marburg Virus In Ghana

NCDC Director-General Dr Ifedayo Adetifa said this in a statement on Tuesday.

The outbreak in Ghana was confirmed by the World Health Organisation (WHO) on Monday and represents the second time the virus will be detected in West Africa. It had been detected in Guinea in August 2021.

Two unrelated males aged 26 and 51 in Ghana were confirmed have been infected by the virus which causes a rare, highly infectious disease and severe haemorrhagic fever (MVD) in humans and non-human primates just like the Ebola virus. Both men died from the disease. There is currently no cure for the virus.

“Given the proximity of Ghana to Nigeria as well as the WHO alert, the NCDC-led multisectoral National Emerging Viral Haemorrhagic Diseases Working Group (EVHDWG) that coordinates preparedness efforts for MVD, and other emerging viral haemorrhagic diseases has conducted a rapid risk assessment to guide in-country preparedness activities,” NCDC Director-General, Dr Adetifa, said in the statement.

“Based on available data, the overall risk of both importation of the disease and its potential impact on the Nigerian population is said to be moderate as assessed by NCDC experts and partners given the following: the proximity (same region), high traffic from Ghana and countries that share borders with Ghana, the incubation period of 21 days of the virus, heightened surveillance at point of entry, Nigeria’s capacity to respond to the outbreak in the country and the fact that persons with MVD transmit the virus when they become symptomatic unlike for SARS-CoV-2 that causes COVID-19 that can also be transmitted by infected persons without symptoms.”

According to the NCDC DG, Nigeria has the capacity to test for the disease that was first discovered in 1967 after outbreaks in Marburg and Frankfurt, Germany.

Testing for the virus can currently be done at the National Reference Laboratory in Abuja and the University of Lagos Teaching Hospital laboratory Centre for Human and Zoonotic Virology.

Dr Adetifa added, “Diagnostic capacity can be scaled up to other laboratories if required. Nigeria has the resources (human, technical and laboratory) for prompt identification and management in the event of a single imported case.”

Even with the measures in place including increased surveillance by the authorities in neighbouring Benin Republic and Togo, the NCDC boss believes changes may be needed.

“The response situation may change in the coming days with the control efforts in Ghana and advisories as may be issued by the World Health Organisation. In addition, many of the contacts under follow-up in Ghana will soon exit the 21-day quarantine period and so far, there have been no secondary cases reported,” he said.

The NCDC DG urged Nigerians to adhere strictly to preventive the following preventive measures.

Avoid non-essential travel to locations where the outbreak is reported for the moment

Avoid direct contact with blood, saliva, vomit, urine, and other bodily fluids of people with suspected or confirmed Marburg virus disease

Avoid the animal reservoir (fruit bats), other sick animals.

Ensure all persons with the symptoms described above are promptly taken to healthcare facilities for diagnosis and initiation of supportive treatment

In suspected and/or confirmed MVD cases, direct physical contact should be avoided by ensuring strict isolation, the use of protective gowns, masks, gloves and safe disposal of needles, bedding, and other contaminated materials

Strict practice of infection prevention control in the healthcare setting for all suspected patients.

Male survivors of Marburg virus disease should practice safer sexual practices and hygiene for 12 months from onset of symptoms or until their semen test negative twice for the virus

 

NCDC on High Alert Following Second Incidence of Marburg Virus Disease Detected in West Africa

The Nigeria Centre for Disease Control and Prevention (NCDC) is aware of the declaration of an outbreak of Marburg virus disease (MVD) in Ghana confirmed by the World Health Organization (WHO) on the 17th of July 2022. This is the second time this zoonotic disease has been detected in West Africa following the previous incidence in Guinea in August 2021. The cases were reported in two unrelated males – 26 and a 51 years old – who both died from the disease. The disease was first discovered in 1967 following outbreaks in Marburg and Frankfurt in Germany, and Belgrade, Serbia. Since then, outbreaks and sporadic cases have been reported in some African countries.

Ghanaian public health officials are responding with support from WHO to halt the spread of the disease. Given the proximity of Ghana to Nigeria as well as the WHO alert, the NCDC-led multisectoral National Emerging Viral Haemorrhagic Diseases Working Group (EVHDWG) that coordinates preparedness efforts for MVD, and other emerging viral haemorrhagic diseases has conducted a rapid risk assessment to guide in-country preparedness activities.

Based on available data, the overall risk of both importation of the disease and its potential impact on the Nigerian population is said to be Moderate as assessed by NCDC experts and partners given the following: the proximity (same region), high traffic from Ghana and countries that share borders with Ghana, the incubation period of 21 days of the virus, heightened surveillance at point of entry, Nigeria’s capacity to respond to the outbreak in country and the fact that persons with MVD transmit the virus when they become symptomatic unlike for SARS-CoV-2 that causes COVID-19 that can also be transmitted by infected persons without symptoms.

Nigeria has the capacity to test for the virus presently at the National Reference Laboratory in Abuja and the University of Lagos Teaching Hospital laboratory Centre for Human and Zoonotic Virology. Diagnostic capacity can be scaled up to other laboratories if required. Nigeria has the resources (human, technical and laboratory) for prompt identification and management in the event of a single imported case.

However, the risk of importation may be further reduced as the current situation in Ghana is under control as reported by Ghana Health Service. Active case finding is ongoing in Ghana while there is heightened surveillance in Togo and Benin. Therefore, the response situation may change in the coming days with the control efforts in Ghana and advisories as may be issued by the World Health Organisation. In addition, many of the contacts under follow-up in Ghana will soon exit the 21-day quarantine period and so far, there have been no secondary cases reported.

Currently, no case of Marburg virus disease has been reported in Nigeria. However, several measures are being put in place to prevent an outbreak of the disease in-country. The National Reference Laboratory has the capacity to test for MVD, point of entry surveillance has been heightened, trained rapid response teams are on standby to be deployed in the event of an outbreak and the NCDC’s Incident Coordination Centre (ICC) is in alert mode. The NCDC is also amplifying risk communication efforts and continues to work with States and partners to strengthen preparedness activities which include– review of risk communication protocols, plans and messages in the event of an outbreak.

About Marburg Virus Disease (MVD)

The Marburg virus causes a rare, highly infectious disease and severe haemorrhagic fever (MVD) in humans and non-human primates just like the Ebola virus, its closest relation and only other member of the Filoviridae family of viruses. It is another example of a zoonosis such as Lassa fever, etc. The natural animal reservoir/host are fruit bats (Rousettus aegyptiacus). Following the transmission from infected animals to humans, it spreads in humans through direct contact with the bodily fluids of infected people, and contaminated materials and surfaces. The virus can enter the body through broken skin or mucous membranes in the eyes, nose, or mouth.

The initial symptoms of the disease include sudden onset of fever (Temp ≥37.5OC), chills, headache, body aches which may be accompanied by a rash, most prominent on the chest, back and stomach, nausea/vomiting, chest pain, sore throat, abdominal pain by the fifth day of illness. Increase in severity of illness can be heralded by the appearance of severe watery diarrhoea, jaundice, inflammation of the pancreas, severe weight loss, bleeding from multiple areas, delirium, shock, liver failure, massive haemorrhaging, and multi-organ dysfunction and/or failure. In fatal cases, death occurs often between 8 and 9 days after symptom onset. The case fatality rate for MVD is estimated to be 24% to 88%.

The Marburg virus is known to persist in the body – placenta, amniotic fluid, foetus of infected pregnant women, breast milk of women who were infected while breastfeeding and semen – of persons who have recovered from MVD.

Nigerians are urged to adhere strictly to the following preventive measures

Avoid non-essential travel to locations where the outbreak is reported for the moment.

Avoid direct contact with blood, saliva, vomit, urine, and other bodily fluids of people with suspected or confirmed Marburg virus disease.

Avoid the animal reservoir (fruit bats), other sick animals.

Ensure all persons with the symptoms described above are promptly taken to healthcare facilities for diagnosis and initiation of supportive treatment/

In suspected and/or confirmed MVD cases, direct physical contact should be avoided by ensuring strict isolation, the use of protective gowns, masks, gloves and safe disposal of needles, bedding, and other contaminated materials.

Strict practice of infection prevention control in the healthcare setting for all suspected patients.

Male survivors of Marburg virus disease should practice safer sexual practices and hygiene for 12 months from onset of symptoms or until their semen test negative twice for the virus.

Infections have been recorded in health facilities and in healthcare workers while looking after patients with suspected or confirmed MVD. This is mostly due to poor adherence to infection prevention and control (IPC) measures. Therefore, healthcare workers are urged to maintain a high index of suspicion for the disease and always observe standard precautions.

There is currently no treatment or vaccine for MVD, however, infected persons can benefit from supportive care and treatment of specific symptoms which improve the chances of survival. Early detection and treatment improve prognosis. Anyone who travels to a location where an outbreak has been reported or had contact with a confirmed case or sick individual of unknown source of illness should observe self-isolation for 21 days and call the NCDC hotline (6232) immediately if symptomatic.

For further information on Marburg virus disease, visit the NCDC website via – https://ncdc.gov.ng/diseases/info/M.

Signed:

Dr. Ifedayo Adetifa

Director General

Nigeria Centre for Disease Control