He is regarded as one of the pioneers of hip-hop music in Nigeria.
More than 20 years after he launched his music career, the 44-year-old musician remained relevant in the industry until his demise.
His death was announced in a statement Sunday morning by his family.
According to the family, Sound Sultan died of Angioimmunoblastic T-cell Lymphoma.
Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkin lymphoma, which is a group of related malignancies (cancers) that affect the lymphatic system (lymphomas).
According to National Organization for Rare Disorders (NORD), the lymphatic system functions as part of the immune system and helps to protect the body against infection and disease.
The exact, underlying cause of AITL is unknown. It is believed that a dysfunctional immune system response to an unknown antigen ultimately leads to the development of the disorder.
A key and differentiating aspect of AITL is dysfunction of the immune system, which can lead to a variety of symptoms.
Affected individuals may develop a rash, persistent fever, unintended weight loss, tissue swelling due to the accumulation of fluid (edema) and additional symptoms.
In May, reports had claimed the musician was flown abroad to commence chemotherapy following his throat cancer diagnosis.
His elder brother, Baba Dee, debunked the rumour he had brother throat cancer and was being treated in the United States.
But many fans and well-wishers prayed for his speedy recovery through social media posts.
Reacting, Sound Sultan had express gratitude to his well-wishers, insisting he would tell the story of his struggles himself.
He said: “I must not ignore the massive show of love. Thank you all. I will tell you my story myself it will be true THEN not false.”
Sound Sultan, has been married to his long-time girlfriend, Chichi Morah, since October 1, 2009 with whom he had three children